Abstract
Subjective cognitive decline (SCD) is defined as a memory complaint in individuals without an objective measure of cognitive impairment. In this study, we investigated the morphometric and metabolic brain changes in individuals presenting with SCD. Age and sex matched structural MRI and [18F]FDG PET images from SCD and CU (n = 101, per group) were extracted from the ADNI database. We built general linear models corrected for multiple comparisons with 10,000 Monte-Carlo simulations to verify differences in cortical thickness between groups, using age as a covariate (Freesurfer’s v7.1.1). Metabolic analysis was performed using voxel-wise general linear models comparing the SUVR of the FDG signal, correcting for age and APOE4 allele carrying status, using the MINC toolkit and the R statistical program. Subjective cognitive decline (SCD) is defined as a memory complaint in individuals without an objective measure of cognitive impairment. In this study, we investigated the morphometric and metabolic brain changes in individuals presenting with SCD. Compared to CU individuals, SCD subjects showed increased cortical thickness in the right hemisphere rostral middle frontal gyrus, while glucose metabolism was increased in the right medial temporal lobe, including the hippocampus, and right occipital cortex.
Guilherme Bauer Negrini
Biomedical Data Scientist | Postdoctoral Associate
Biomedical Informatics and Science