circrna

We have identified over 130,000 unique circRNAs in 6 mouse models of ASD. DECs per se are shared by a few animal models. However, functional analysis revealed that the DECs from distinct models share a similar profile of changes, mostly related to synaptic structure and function. Regarding translational alterations, around 2% of DECs in mice are orthologous to DECs in autistic individuals. We hope the broad identification of circRNAs can help researchers further explore their selected mouse models.

We developed a set of 15 heuristics to evaluate the usability of four circRNAs identification tools. Cosmetic and minor severity issues are present in all tools evaluated. Severe problems are less frequent but affect critical parts of the software. The use of heuristics could help promptly evaluate usability during the development cycle.

This repository contains files to reproduce the heuristic evaluation environment described in the paper “Usability evaluation of circRNA identification tools - Development of a heuristic-based framework and analysis”.