We have identified over 130,000 unique circRNAs in 6 mouse models of ASD. DECs per se are shared by a few animal models. However, functional analysis revealed that the DECs from distinct models share a similar profile of changes, mostly related to synaptic structure and function. Regarding translational alterations, around 2% of DECs in mice are orthologous to DECs in autistic individuals. We hope the broad identification of circRNAs can help researchers further explore their selected mouse models.