ASD

A comprehensive bioinformatics analysis of circRNA expression in the brain of distinct mouse models of Autism Spectrum Disorder
We have identified over 130,000 unique circRNAs in 6 mouse models of ASD. DECs per se are shared by a few animal models. However, functional analysis revealed that the DECs from distinct models share a similar profile of changes, mostly related to synaptic structure and function. Regarding translational alterations, around 2% of DECs in mice are orthologous to DECs in autistic individuals. We hope the broad identification of circRNAs can help researchers further explore their selected mouse models.
Guilherme Bauer Negrini, Guilherme Cordenonsi da Fonseca, Carmem Gottfried
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A comprehensive bioinformatics analysis of circRNA expression in the brain of distinct mouse models of Autism Spectrum Disorder