bioinformatics

We have identified over 130,000 unique circRNAs in 6 mouse models of ASD. DECs per se are shared by a few animal models. However, functional analysis revealed that the DECs from distinct models share a similar profile of changes, mostly related to synaptic structure and function. Regarding translational alterations, around 2% of DECs in mice are orthologous to DECs in autistic individuals. We hope the broad identification of circRNAs can help researchers further explore their selected mouse models.

Esse repositório contém arquivos para reproduzir o ambiente de avaliação heurística descrito no artigo “Usability evaluation of circRNA identification tools - Development of a heuristic-based framework and analysis”.

We developed a set of 15 heuristics to evaluate the usability of four circRNAs identification tools. Cosmetic and minor severity issues are present in all tools evaluated. Severe problems are less frequent but affect critical parts of the software. The use of heuristics could help promptly evaluate usability during the development cycle.

Design patterns de interação para ajudar os desenvolvedores de software de bioinformática a melhorar a produtividade e a eficiência de seu processo de design.

Ferramenta de linha de comando para automatizar a busca por alvos microRNA na base miRDB e extrair o número de sítios de ligação